Immediate hypersensitivity reactions to parenteral cyclosporine in patients with thalassemia major undergoing hematopoietic stem cell transplantation: a case report and review of the literature

Table 1 Characteristics of the cases

Variable				Case
	Case 1 (AD)	Case 2 (MT)	Case 3 (AR)	Case 4 (AT)
Patient information
Age (years)	19	17	10	20
Sex	Female	Male	Male	Male
Race	Caucasian	Caucasian	Caucasian	Caucasian
Allergy history	N/A^c	N/A	N/A	N/A
History of splenectomy	No	No	No	No
Hepatitis B infection	Reactive HBcAb^d	No	No	No
Disease information
Classification^a	III	II	II	III
Liver size	Mild hepatomegaly	Normal	Normal	Mild hepatomegaly
Hepatic iron load	Very severe	Mild	Moderate	Mild
Transfusion dependency	Yes	Yes	Yes	Yes
Ferritin (ng/mL)	> 2000	> 2000	> 2000	1297
Transfusion-receiving information
Onset age (months)	6	6	7	12
Frequency	Every 20 days	Every 20 days	Every 20 days	Every 14 days
Antigen typing	No	No	No	No
Donor information:
Relationship	Sibling	Unrelated	Sibling	Sibling
Matching	Full match	Full match	Full match	Full match
Transplant information
Source	PB^e	PB	PB	PB
Conditioning	MAC^f	MAC	MAC	MAC
Hospital length of stay (days)	49	75	43	42
CsA total daily dose^b (mg/kg)	1.5	1.5	1.5	1.5

^a Based on Lucarelli et al. (1990)
^b At the time of the reaction
^c N/A, not available; ^d HBcAb, hepatitis B core antigen; ^e PB, peripheral blood; ^f MAC, myeloablative conditioning

ISSN: 1752-1947